|
KMID : 0897520100150010023
|
|
Journal of Korean Association of Social Psychiatry
2010 Volume.15 No. 1 p.23 ~ p.29
|
|
|
Time to Discontinuation of Venlafaxine and Olanzapine Augmentation Group With Major Depressive Disorder During 6Mmonths
|
|
Park Hyun-Woo
Jang Sae-Heon
Jae Young-Myo
Lee Dae-Su
Choi Jin-Hyuk
|
|
|
Abstract
|
|
|
Objectives： Antipsychotics augmentation is suggested as one of the strategies to improve the effectiveness of antidepressants in the treatment of major depressive disorder. This study calculated time to discontinuation of venlafaxine monotherapy group and olanzapine augmentation group with major depressive disorder during 6 months and discussed the effectiveness of olanzapine augmentation.
Methods: We collected the data from medical records of patients who visited psychiatric outpatient clinic of Bongseng memorial hospital and were prescribed by venlafaxine XR alone, or combination of venlafaxine XR and olanzapine on first visit from Aug. 2006 to Aug. 2007. We measured time to discontinuation (no more visit), the degree of adherence by medication possession ratio (MPR) from first visit until 6 months. The degree of CGI-I, CGI-S scores and dosages of each medication were also assessed by monthly for 6 months. We used chi-square test and t-test, Kaplan Meier method to analyze group differences in demographic data and clinical characteristics, treatment efficacy and survival analysis.
Results： The mean survival time of augmentation group was longer than monotherapy group (129.55 days vs 99.86 days, log rank test p=0.0342). The difference of CGI-S between two groups was not different significantly (4.4 vs 4.3, p=0.743) at baseline but CGI-I of augmentation group was better than monotherapy group (1.8 vs 2.8, p<0.001) at first month. Augmentation group showed higher MPR than monotherapy group but statistically not significant (0.950 vs 0.908, p=0.351).
Conclusion： Our results suggest olanzapine augmentation would be able to increase treatment adherence and effectiveness.
|
|
|
KEYWORD
|
|
|
Depression, Antipsychotics augmentation, Time to discontinuation, Effectiveness
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|